passionless Droning about autism

Alpha Post!

Posted on: April 10, 2009


Hello friends –

Join us for discussions about findings in the world of autism.  

Discussion of controversial topics is encouraged, providing it is done with some level of intelligence.  Sarcasm is recommended, and extreme sarcasm may be rewarded.  There will be no moderation.

Advertisements

9 Responses to "Alpha Post!"

Hi pD,

Good post. This hits on several important points that somehow get overlooked when discussing autism. Wonder why? It seems as though many people are quite content drawing categorical conclusions about the causes or “non causes” of autism without having the slightest clue about the underlying genetics/biochemistry.

For me, It seems a logical place to start, that is, start unravelling the etiology of autism. I agree with you regarding the multifaceted approach to understanding the cause of autism (barring the inherited forms). Do you think that each individual has their own specific “fingerprint” so to say when it comes to the etiology of autism?

It seems like the best way to start isolating patterns amongst children with ASD is to utilize bioinformatics in a way that catalogues the many different factors inherent in an autistic child. Then catalogue as much biochemical, genetic and environmental data as possible, from as many kids with ASD as possible. Once all this data is organized into a bioinformatic system then it could be analyzed for patterns, this could at least help the research and maybe assist the developments of therapeutics (which could also be catalogued as to its efficacy/side effects). Bioinformatics is not my forte, and this maybe a monumental task, but it just seems like it is the only way to effectively look at the “multifaceted etiology of autism”

Hi skeptiquette –

Thanks for stopping by!

We share many common thoughts.

Do you think that each individual has their own specific “fingerprint” so to say when it comes to the etiology of autism?

Yes! There just seem to be too many disparate physiological findings for there to be another way; I’ve seen a few groups trying to find ways to break autism up into discernable phenotypes; this would be a big help.

I think that having this well defined will go a long ways towards more gracefully designed epidemiology research. Our only mechanism for diagnosing autism is so sloppy, lots of studies are likely including scads of children that have a different set of causes and applied at a large group level find a lack of an association due to inappropriate selection, as opposed to reality. That actually sounds like a nice topic for a post.

It seems like the best way to start isolating patterns amongst children with ASD is to utilize bioinformatics in a way that catalogues the many different factors inherent in an autistic child. Then catalogue as much biochemical, genetic and environmental data as possible, from as many kids with ASD as possible. Once all this data is organized into a bioinformatic system then it could be analyzed for patterns, this could at least help the research and maybe assist the developments of therapeutics (which could also be catalogued as to its efficacy/side effects).

I believe that in all of my arguing with folks on the Internet, this is the first time someone has used the word ‘bioinformatics’. Very nicely done.

Eventually, I think that we will be able to accumulate enough information and throw a processor at it in able to answer the other big mystery about autism; is there more of it? Or at least the answer to, are there more twenty year old people now with this pattern of biological profiles than there were ten years ago?

There are efforts to do some of this already underway. MARBLES, and CHARGE, both at the University of California, Davis. This group of researchers has been producing voluminious research based on the data they’ve been accumulating and have some very exciting findings. Many more are in the pipeline.

I’m betting that some of their efficiency is based on an economy of scale principle in having so much data available. I’ve had my son participate in a genetic study on autism; it took the lead author half a day, and her graduate student an entire day to process us; then, during the last five minutes they drew blood. But the cost in time to researchers was extreme, because they had to give Luke their own little autism diagnosis and catalog his behaviors themselves. The guys at UC though, have a big bank of all kinds of goodies they can whip out with relative ease.

I also happen to think that they are on the right track in many ways. Check out recent papers by Ashwood, Enstrom, Van de Water for more.

– pD

Hi pD,

Keep writing…

What’s up friends, how is all, and what you would like
to say regarding this paragraph, in my view its truly awesome designed for me.

It’s a shame you don’t have a donnate button! I’d mostt certainly donate tto this excellent blog!
I supposse forr now i’ll settle for bookmarking
and adding your RSS feed to my Googgle account.
I look forward to new updates aand will talk about this
blog with my Facebook group. Chat soon!

Heey ѵery intеresting blog!

If you find that her mood is beginning to change due to subject you are
discussing alter the topic immediately. Following browsing the e-book only for a couple of minutes you’ll
understand simply how little you know. Loving,
Caring, Comforting,Giving and appreciating space,
And preserving the relationship for both
the short and also the long haul.

Nonetheless, to kill a Sasquatch signifies to destroy what is probably an endangered species, and it
also implies ending the existence of a sentient becoming.

It’s in reality a nice and useful piece of info.
I am glad that you shared this helpful information with us.

Please stay us up to date like this. Thank you for sharing.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 36 other followers


    • here: First of all I would like to say fantastic blog! I had a quick question that I'd like to ask if you don't mind. I was interested to know how you cen
    • What is forum seeding: Wow, that's what I was looking for, what a data! existing here at this blog, thanks admin of this web page.
    • Ibalance: Thank you for your time and effort. I first learnt about the early year challenge from Dr Suzanne Humphries. Your post provided more filling in the bl
    %d bloggers like this: